Gary’s Daily Health News - Vol. 5

Drinking sufficient water could prevent heart failure

National Heart, Lung, and Blood Institute (US), 24 Aug 2021

Staying well hydrated throughout life could reduce the risk of developing heart failure, according to research presented at ESC Congress 2021.1

“Our study suggests that maintaining good hydration can prevent or at least slow down the changes within the heart that lead to heart failure,” said study author Dr. Natalia Dmitrieva of the National Heart, Lung, and Blood Institute, part of the National Institutes of Health, Bethesda, US. “The findings indicate that we need to pay attention to the amount of fluid we consume every day and take action if we find that we drink too little.”

Recommendations on daily fluid intake vary from 1.6 to 2.1 litres for women and 2 to 3 litres for men. However, worldwide surveys have shown that many people do not meet even the lower ends of these ranges.2 Serum sodium is a precise measure of hydration status: when people drink less fluid, the concentration of serum sodium increases. The body then attempts to conserve water, activating processes known to contribute to the development of heart failure.

Dr. Dmitrieva said: “It is natural to think that hydration and serum sodium should change day to day depending on how much we drink on each day. However, serum sodium concentration remains within a narrow range over long periods,3 which is likely related to habitual fluid consumption.”

This study examined whether serum sodium concentration in middle age, as a measure of hydration habits, predicts the development of heart failure 25 years later. The researchers also examined the connection between hydration and thickening of the walls of the heart's main pumping chamber (left ventricle) – called left ventricular hypertrophy – which is a precursor to heart failure diagnosis.

The analysis was performed in 15,792 adults in the Atherosclerosis Risk in Communities (ARIC) study. Participants were 44 to 66 years old at recruitment and were evaluated over five visits until age 70 to 90.

Participants were divided into four groups based on their average serum sodium concentration at study visits one and two (conducted in the first three years): 135–139.5, 140–141.5, 142–143.5, and 144–146 mmol/l. For each sodium group, the researchers then analysed the proportion of people who developed heart failure and left ventricular hypertrophy at visit five (25 years later).

Higher serum sodium concentration in midlife was associated with both heart failure and left ventricular hypertrophy 25 years later. Serum sodium remained significantly associated with heart failure and left ventricular hypertrophy after adjusting for other factors related to the development of heart failure: age, blood pressure, kidney function, blood cholesterol, blood glucose, body mass index, sex and smoking status. Every 1 mmol/l increase in serum sodium concentration in midlife was associated with 1.20 and 1.11 increased odds of developing left ventricular hypertrophy and heart failure, respectively, 25 years later.

The risks of both left ventricular hypertrophy and heart failure at age 70 to 90 began to increase when serum sodium exceeded 142 mmol/l in midlife.

Dr. Dmitrieva said: “The results suggest that good hydration throughout life may decrease the risk of developing left ventricular hypertrophy and heart failure. In addition, our finding that serum sodium exceeding 142mmol/l increases the risk of adverse effects in the heart may help to identify people who could benefit from an evaluation of their hydration level. This sodium level is within the normal range and would not be labelled as abnormal in lab test results but could be used by physicians during regular physical exams to identify people whose usual fluid intake should be assessed.”

 

High cholesterol fuels cancer by fostering resistance to a form of cell death

Most cancer cells die under the stress of metastasis, but cholesterol fuels a process that makes them impervious to stress-induced cell death

Duke University, August 24, 2021

Chronically high cholesterol levels are known to be associated with increased risks of breast cancer and worse outcomes in most cancers, but the link has not been fully understood.

In a study appearing online Aug. 24 in the journal Nature Communications, a research team led by the Duke Cancer Institute has identified the mechanisms at work, describing how breast cancer cells use cholesterol to develop tolerance to stress, making them impervious to death as they migrate from the original tumor site.

“Most cancer cells die as they try to metastasize -- it’s a very stressful process,” said senior author Donald P. McDonnell, Ph.D., professor in the departments of Pharmacology and Cancer Biology and Medicine at Duke University School of Medicine. “The few that don’t die have this ability to overcome the cell’s stress-induced death mechanism. We found that cholesterol was integral in fueling this ability.”

McDonnell and colleagues built on earlier research in their lab focusing on the link between high cholesterol and estrogen-positive breast and gynecological cancers. Those studies found that cancers fueled by the estrogen hormone benefitted from derivatives of cholesterol that act like estrogen, stoking cancer growth.

But a paradox emerged for estrogen-negative breast cancers. These cancers are not dependent on estrogens, but high cholesterol is still associated with worse disease, suggesting a different mechanism might be at work.

In the current study using cancer cell lines and mouse models, the Duke researchers found that migrating cancer cells gobble cholesterol in response to stress. Most die.

But in the what-doesn’t-kill-you-makes-you-stronger motif, those that live emerge with a super-power that makes them able to withstand ferroptosis, a natural process in which cells succumb to stress. These stress-impervious cancer cells then proliferate and readily metastasize.

The process appears to be used not only by ER-negative breast cancer cells, but other types of tumors, including melanoma. And the mechanisms identified could be targeted by therapies.

“Unraveling this pathway has highlighted new approaches that may be useful for the treatment of advanced disease,” McDonnell said. “There are contemporary therapies under development that inhibit the pathway we’ve described. Importantly, these findings yet again highlight why lowering cholesterol -- either using drugs or by dietary modification -- is a good idea for better health.”

 

Drinking green tea may be protective against Alzheimer disease

Anhui Agricultural University, August 23, 2021

The following information was released by the Chinese Academy of Sciences:

Chinese scientists have found that drinking green tea may help prevent Alzheimer's disease, Science and Technology Daily reported Monday.

With population aging deepening, neurodegenerative diseases, including Alzheimer's disease, are showing rapid high incidence rates.

Scientists from Anhui Agricultural University and the University of Science and Technology of China have revealed that green tea could help reduce synaptic damage and improve learning and memory.

The study provides a theoretical basis for revealing the mechanism of preventing Alzheimer's disease by drinking tea and its further application.

The study was recently published in the journal Molecular Nutrition and Food Research. 

 

 

Effects of one month of Common Yoga Protocol practice appear to be mediated by the angiogenic and neurogenic pathway: A pilot study

Post Graduate Institute of Medical Education and Research (India), August 19, 2021

 

To examine the molecular effects of mindful activities such as yoga and meditation. Common Yoga Protocol includes asanas, pranayama and meditation practice. Markers of angiogenesis and neurogenesis were analyzed before and after one month of Common Yoga Protocol practice in healthy adults.

Study participants

64 healthy individuals within the age of 18–60 years were recruited for this one month yoga intervention study. The participants were assessed for biochemical parameters including Fasting Sugar and Lipid profile. The molecular markers of neurogenesis (i.e. Brain derived Neurotropic Factor, BDNF) and Angiogenesis (i.e. Vascular Endothelial Growth Factor, VEGF and Angiogenin) along with Amyloid β (marker related to neuro-degenerative diseases) were assessed. All the assessments were made at baseline and after one month of the intervention.

Results

After one month of CYP practice High Density Lipoprotein (HDL) levels increased significantly (p<0.001), although other biochemical parameters i.e. fasting sugar and other lipid assessments were found to be unaltered. Angiogenesis marker, angiogenin was increased significantly (p<0.002), other angiogenesis marker VEGF did not show any change along with BDNF, marker of neurogenesis. Amyloid β levels were also unaltered. Even though individual levels of VEGF and Amyloid β did not show any change, proportion of VEGF to Amyloid β showed a significant increase (p<0.001) after one month of CYP intervention indicating that the change in VEGF levels was significantly higher than the change in Amyloid β levels.

Conclusion

CYP practice may influence cell survival pathways mediated by angiogenic and neurogenic cross talk. Hence, CYP can be considered as a preventive measure for diseases associated with impaired angiogenic and neurogenic mechanism. This is the first study to examine the effects of CYP at the molecular level.

 

 

Anti-aging tricks from dietary supplement seen in mice

Alpha-lipoic acid stimulates telomerase in vascular smooth muscle

Emory University, August 21, 2021

 

In human cells, shortened telomeres, the protective caps at the ends of chromosomes, are both a sign of aging and contribute to it. Scientists at Emory University School of Medicine have found that the dietary supplement alpha lipoic acid (ALA) can stimulate telomerase, the enzyme that lengthens telomeres, with positive effects in a mouse model of atherosclerosis.

The discovery highlights a potential avenue for the treatment for chronic diseases.

The results were published  in Cell Reports.

"Alpha-lipoic acid has an essential role in mitochondria, the energy-generating elements of the cell," says senior author Wayne Alexander, MD, PhD, professor of medicine at Emory University School of Medicine. "It is widely available and has been called a 'natural antioxidant'. Yet ALA's effects in human clinical studies have been a mixed bag."

ALA appears to exert its effects against atherosclerosis by spurring the smooth muscle cells that surround blood vessels to make PGC1 (peroxisome proliferator-activated receptor gamma co-activator 1)-alpha. PGC1-alpha was already well known to scientists as controlling several aspects of how skeletal muscles respond to exercise. While the Emory researchers did not directly assess the effects of exercise in their experiments, their findings provide molecular clues to how exercise might slow the effects of aging or chronic disease in some cell types.

"The effects of chronic diseases such as atherosclerosis and diabetes on blood vessels can be traced back to telomere shortening," Alexander says. "This means that treatments that can restore healthy telomeres have great potential."

"What's new here is that we show that PGC1-alpha is regulating telomerase, and that has real beneficial effects on cellular stress in a mouse model of atherosclerosis," says Shiqin Xiong, PhD, instructor in the division of cardiology and first author of the paper.

Xiong and Alexander used a model of atherosclerosis where mice lacked the ApoE cholesterol processing gene and were fed a high-fat diet. In this model, mice also lacking PGC1-alpha have more advanced plaques in their blood vessels, but only in older animals, the authors show.

Consistent with the poorer state of their blood vessels, aortic cells from PGC1-alpha-disrupted mice had shorter telomeres and reduced telomerase activity. Having shortened telomeres led the smooth muscle cells to display more oxidative stress and damage to the rest of their DNA.

The authors show that introducing PGC1-alpha back into vascular smooth muscle cells lacking that gene with a gene-therapy adenovirus could restore telomerase activity and lengthen the cells' telomeres.

Telomerase is off in most healthy cell types and only becomes turned on when cells proliferate. Because telomerase is active in cancer cells and enables their continued growth, researchers have been concerned that stimulating telomerase in all cells might encourage cancer growth or have other adverse effects.

As a way to boost PGC1-alpha in cells more conveniently, Xiong and Alexander turned to alpha lipoic acid or ALA. ALA is a sulfur-containing fatty acid used to treat diabetic neuropathy in Germany, and has previously been shown to combat atherosclerosis in animal models.

Treating isolated smooth muscle cells with ALA for one day could both stimulate PGC1-alpha and telomerase, the authors found. ALA's effects on vascular smooth muscle cells could also be seen when it was injected into mice. Xiong and Alexander say they are now investigating the effects of ALA on other tissues in mice. They have not observed increased cancers in ALA-treated mice, but say more thorough investigation is needed to fully assess cancer risk.

"While ALA is present in many foods and its effects in animal models look promising, it may be problematic for clinical use because of its poor solubility, stability and bioavailability," Xiong says. "We are designing new ways to formulate and deliver ALA-related compounds to resolve these issues."

 

 

 

Disaggregation behavior of amyloid beta fibrils by anthocyanins

Osaka University Graduate School of Medicine (Japan), August 20, 2021

According to news originating from Osaka, Japan,research stated, “Amyloid fibrils are formed from various proteins, some of which cause the corresponding neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. It has been reported that many compounds inhibit the formation of amyloid fibrils.”

Our news journalists obtained a quote from the research from the Osaka University Graduate School of Medicine, “Anthocyanins are flavonoid pigments present in fruits and vegetables -- notably all dark berries, black plums and red cabbage --  which are known to suppress symptoms related with Alzheimer’s disease. However, the influence of anthocyanins on the amyloid fibril remains unclear. Here, we succeeded in the direct monitoring of the disaggregation reaction of single amyloid b (Ab) fibrils by anthocyanins using total-internal-reflection-fluorescence microscopy with a quartz-crystal microbalance (TIRFM-QCM). It is found that the disassembly activity to the Ab fibrils depends on the number of hydroxyl groups in six-membered ring B of anthocyanin, and only delphinidin-3-galactoside, possessing three hydroxyl groups there, shows high disassembly activity.”

According to the news editors, the research concluded: “Our results show the importance of the number of hydroxyl groups and demonstrate the usefulness of TIRFM-QCM as a powerful tool in studying interactions between amyloid fibrils and compounds.”

This research has been peer-reviewed.

 

 

Men, people over 65 sleep better when they have access to nature 

University of Illinois College of Agricultural, August 24, 2021

Men and persons age 65 and older who have access to natural surroundings, whether it's the green space of a nearby park or a sandy beach and an ocean view, report sleeping better, according to a new University of Illinois study published in Preventive Medicine. 

"It's hard to overestimate the importance of high-quality sleep," said Diana Grigsby-Toussaint, a U of I professor of kinesiology and community health and a faculty member in the U of I's Division of Nutritional Sciences. "Studies show that inadequate sleep is associated with declines in mental and physicalhealth, reduced cognitive function, and increased obesity. This new study shows that exposure to a natural environment may help people get the sleep they need." 

In the study, Grigsby-Toussaint worked with both U of I researchers and scientists from the New York University School of Medicine. The team used data from the CDC's Behavioral Risk Factor Surveillance System, which surveyed 255,171 representative U.S. adults, to learn whether there was an association between self-reported days of insufficient sleep and access to green space. The team also used a USDA index that scores the country's geographical areas for their natural amenities, using hours of sunlight, which is important in regulating a person's circadian rhythm, and temperature.

In response to the survey question about sleep quality in the last month, the researchers found that the most common answer was that respondents had slept poorly for less than one week.

"Interestingly, though, across the entire sample, individuals reporting 21 to 29 days of insufficient sleep consistently had lower odds of access to green space and natural amenities compared to those reporting less than one week," she said.

For men, the relationship between sleep and exposure to green space was much stronger than for women. And males and females 65 and over found nature to be a potent sleep aid, she added.

Grigsby-Toussaint noted that living near green landscapes is associated with higher levels of physical activity and that exercise in turn predicts beneficial sleep patterns.

But men appeared to benefit much more from their natural surroundings. The researcher speculated that women may take less advantage of nearby natural settings out of concern for their safety, but she added that more research is needed.

The finding should be a boon for people who are having trouble sleeping as they age. "If there is a way for persons over 65 to spend time in nature, it would improve the quality of their sleep--and their quality of life--if they did so," Grigsby-Toussaint said.

The study points to the importance of conserving nature in general, she added.

"And, specifically, our results provide an incentive for nursing homes and communities with many retired residents to design buildings with more lighting, create nature trails and dedicated garden spaces, and provide safe outdoor areas that encourage outdoor activity for men and women," she said.